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apalutamide will lower the level or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with prescription drugs which can be CYP2C19 substrates may result in decreased publicity to those medications.tazemetostat will minimize the leve